Combined contribution of increased intestinal permeability and inhibited deglycosylation of ginsenoside Rb1 in intestinal tract to the enhancement of ginsenoside Rb1 exposure in diabetic rats following oral administration
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منابع مشابه
Dmd064881 1702..1710
Panax ginseng is becoming a promising antidiabetic herbal medication. As the main active constituents of Panax ginseng, ginsenosides are well known, poorly absorbed chemicals. However, the pharmacokinetic behavior of ginsenosides under diabetic conditions is not fully understood. This study aimed to explore the alterations and potential mechanisms of pharmacokinetic behavior of ginsenoside Rb1 ...
متن کاملBiol. Pharm. Bull. 28(10) 1903—1908 (2005)
Araliaceae) is frequently used as a traditional medicine, taken orally, in China, Korea, Japan and other Asian countries. The major components of ginseng, the ginsenosides, are glycosides that contain an aglycone with a dammarane skeleton. These ginsenosides have been reported to show various biological activities, including immunomodulatory effect, anti-inflammatory activity and antitumor effe...
متن کاملGinsenoside Rb1 protects the intestinal mucosal barrier following peritoneal air exposure
Ginsenoside Rb1 (GRb1), which is one of the main ingredients derived from Panax ginseng, has been widely used to treat various gastrointestinal disorders. The present study aimed to determine whether GRb1 was able to prevent intestinal mucosal barrier damage in rats following peritoneal air exposure for 3 h. GRb1 (5, 10, and 20 mg/kg) was orally administrated via gavage four times prior to and ...
متن کاملPharmacokinetics of ginsenoside Rb1 and its metabolite compound K after oral administration of Korean Red Ginseng extract
Compound K is a major metabolite of ginsenoside Rb1, which has various pharmacological activities in vivo and in vitro. However, previous studies have focused on the pharmacokinetics of a single metabolite or the parent compound and have not described the pharmacokinetics of both compounds in humans. To investigate the pharmacokinetics of ginsenoside Rb1 and compound K, we performed an open-lab...
متن کاملEffect of a soluble prebiotic fiber, NUTRIOSE, on the absorption of ginsenoside Rd in rats orally administered ginseng
BACKGROUND There is limited understanding of the effect of dietary components on the absorption of ginsenosides and their metabolites into the blood. METHODS This study investigated the pharmacokinetics of the ginseng extract and its main constituent ginsenoside Rb1 in rats with or without pretreatment with a prebiotic fiber, NUTRIOSE, by liquid chromatography tandem mass spectrometry. When g...
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